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Magnesium is Anti-thrombotic and Helps Prevent Blood Clots

Magnesium is Anti-thrombotic and Helps Prevent Blood Clots

What difference can magnesium make to prevent dangerous blood clots?

In Australia blood clots are responsible for the top three cardiovascular killers: stroke, heart attack, and VTE (venous thromboembolism).  Every year about 30,000 Australians develop a thrombosis of some sort, including deep vein thrombosis (DVT) and pulmonary embolism (PE).  

What is a Blood Clot?

After an injury the blood vessel narrows near the injury site to minimize blood loss. Blood clots are plugs made up of red blood cells, platelets and fibrin protein mesh that form around an injury to the endothelial lining, so as to block the breach. Normally this would then trigger white blood cells called macrophages to clean the wound and release growth factors to build new cells and repair tissue. When healing is complete, enzymes like plasmin break down the fibrin strands, restoring blood flow and removing the clot. 

However, the dangerous blood clots are the ones where healing is hindered, the vessel repair fails, and the blood clot is not dissolved.  In this case the clot can grow so big it blocks blood flow and causes a lot of pain. A DVT is a blood clot that has formed in the deep veins of your body – usually in your calves or upper legs.

A pulmonary embolism occurs when a blood clot breaks off from the wall of the vein and travels to your lungs, causing a blockage. A blood clot that forms in an artery is known as an arterial thrombosis. An example of this is a blood clot in the artery of the heart which can lead to myocardial infarction (a heart attack), or a stroke when it forms in the brain.

Hypercoagulation (thrombophilia)

The tendency for hypercoagulation can occur due to genetic inheritance.  The most common genetic risk factor for thrombophilia is Factor V Leiden mutation. It increases the risk of thrombosis by enhanced thrombin production. 

Acquired factors also influence the coagulation cascade and include surgery, pregnancy, hormonal replacement therapy, contraception, malignancy, inflammation, excessive stress, infection, and heparin-induced thrombocytopenia. All of those circumstances involve some kind of micro damage to blood vessels. Problems with the healing phase can occur with liver dysfunction, or in those who are smokers or who drink excessive alcohol.

“Autoimmune diseases like systemic lupus erythematosus, immune thrombocytopenic purpura, polyarteritis nodosa, polymyositis, dermatomyositis, inflammatory bowel disease, and Behcet's syndrome increase the risk of thrombotic events.”
https://www.ncbi.nlm.nih.gov/books/NBK538251/#:~:text=The%20most%20common%20acquired%20thrombophilia,venous%20thrombosis%20and%20fetal%20loss.

Higher Risk for Those with Metabolic Syndrome and Diabetes

Thrombosis, acidosis, and high cortisol levels are interconnected.  Stress hormones trigger the release of cortisol, which can increase pro-thrombotic states, with lower blood oxygen levels leading to the formation of blood clots. Acidosis, particularly lactic acidosis, can itself be a stressor, stimulating the release of stress hormones like cortisol and catecholamines. Therefore, conditions involving acidosis and high cortisol levels increase the risk of thrombosis via inflammatory processes.

When the cell oxygen levels are too low, mitochondria switch to anaerobic (without oxygen) sugar metabolism because you need oxygen to burn the fat (ie. aerobic metabolism). People with metabolic issues crave more carbohydrates to get energy, but end up with excessive blood sugar because they don’t get enough insulin able to take the blood sugar inside cells.

The body then sends the extra glucose and insulin to the liver to process and store mostly as adipose fat around the middle. Sugar metabolism also produces more acidic byproducts, and if the cell cannot neutralise these free radicals called ROS (Reactive Oxygen Species), metabolism slows down by creating resistance for the insulin and blood sugar to get in. The cell protects itself by cutting back metabolism, and therefore production of more waste products, so that antioxidant hormones like glutathione and superoxide dismutase can have a chance to clean up and restore homeostasis (balance).

Acidic states in tissue cells, often a result of inflammatory byproducts, will attract more free calcium to deposit and contribute to hardening of vessels if the pH balance is not addressed. Calcium is a way that the body can alkalise an area subjected to inflammation and acidosis because calcium is an alkalising mineral, but the downside is that the calcium can remain stuck in the tissue of the endothelial linings.

Arterial plaque contains calcium deposits, which over time restricts the flexibility of the vessel wall, and pushes up blood pressure, increasing the risk of micro splits in the lining if blood pressure goes too high. These sites of injury produce more inflammation and potential for clot formation. So it can become a vicious cycle.
“A decrease in blood pH can lead to an increase in the enzymatic activity of coagulation factors, a reduction in the anticoagulant activity of heparin, and an increase in the ability to aggregate platelets, leading to hypercoagulation of the blood and, ultimately, DVT.”
https://www.sciencedirect.com/science/article/abs/pii/S0049384819302956

“Changes in intracellular pH can affect virtually all cellular processes, including metabolism, membrane potential, cell growth, movement of substances across the surface membrane, state of polymerization of the cytoskeleton, and the ability to contract in muscle cells… In addition, changes in pH will affect the water absorption capacity of vein intima epithelial cells, leading to more significant changes in the permeability of blood vessels, such as local redness and swelling of blood vessels, adverse effects on human blood circulation, and decreased metabolic function of vascular intima, which will ultimately affect blood coagulation function.” https://www.nature.com/articles/s41598-023-45712-0

Common medical treatments use blood thinners (anti-coagulants) like aspirin, to thin the blood and help it get past any plaque obstructions. However, current therapies still possess limitations, including increased risk of bleeding – and that includes bleeding in the brain. In acute situations you may have no other choice than to use blood thinners to treat a crisis, so make sure to consult with your doctor regarding medications. Direct oral anticoagulants are often contraindicated in elderly patients (>80 years) and in patients with impaired renal function or advanced cancer.

Dietary magnesium chloride salt (and via skin) to support the body’s needs 

Magnesium is known to have anti-thrombotic effects, but it doesn’t act like a drug blood thinner. Instead, magnesium acts as an electrolyte mediator and regulator to support balance and homeostasis. It does this directly via its antagonism of calcium, and via its co-factoring with enzymes and other nutrients to leverage their effects.  Magnesium is known to be essential for the activity of over 600 enzymes, and we even need magnesium to make proteins – such as collagen, hormones, DNA and enzymes. How does it do all that?  It does so via its role in mitochondrial metabolism and production of the ATP (Adenosine Triphosphate) energy currency - as in biological batter power.  Magnesium in this way works as a power point to support all organs and systems, especially blood and the immune system.

Note that the immune cells are most highly concentrated in endothelial linings of blood vessels, our gut, blood-brain barrier and other tubules of filtering organs like the kidneys.  These sites are critical areas of defence strategy for the body, where breaches by foreign objects or organisms can result in blood sepsis and death. They are therefore more prone to inflammation and its acidic byproducts. If the body’s detoxification system and pH balancing system is dysfunctional, then a cascade of evolving thrombosis and cardiovascular issues are inevitable.

A change in diet to reduce carbohydrates, increase alkalinity, and increase magnesium-rich foods is an essential natural strategy to counterbalance the metabolic-acidic issues that promote thrombosis and other cardiovascular issues. Magnesium protects cells against oxidative stress, which is essential to maintain pH balance, and avoid acidic conditions that lead to thrombosis. 1  You can also assist the body’s pH system by adding a small pinch of bicarbonate of soda per litre of drinking water (along with magnesium chloride drops), and make sure to drink enough water to help your cells rinse and flush.

Sufficient magnesium salt via diet and skin can prevent neuroinflammation and reduce risk of strokes. Read more in this article about magnesium and brain function. Take care also to avoid toxins and chemicals that hinder and block magnesium, such as fluoride, aluminium, mercury and lead (to name a few).

Magnesium helps to prevent hypercoagulability and thrombosis formation, and has been shown to reduce platelet aggregation both in vitro and ex vivo.  This study showed, “Topically applied magnesium significantly decreased the maximum thrombus area, without any increase in serum magnesium level (p<0.05). The magnesium-treated groups showed no increase in bleeding complications. A transient fall in blood pressure was seen in the systemic magnesium group… In conclusion, topically as well as intravenously infused magnesium reduced arterial thrombus formation in this in vivo rat model without compromising haemostasis.” 2   So all those good things happen with magnesium – without interfering with ‘haemostasis’ (and therefore no excessive bleeding events, as can occur with blood thinners).

Did you also notice in the conclusion of this study that they mentioned topically applied magnesium reduced the size of the blood clot (thrombus) without a change in magnesium blood plasma level?  This is because magnesium ions can travel from tissue cell to tissue cell directly via the membrane channels, and are not restricted only to travel via blood. 3 

Dissolved magnesium chloride salt is the most bio-available magnesium that can get right into cells quickly, bypassing the need for digestion. This is why regular soaking and bathing in magnesium, as well as application of Magnesium Cream, Lotion and/or Oil, can help supply optimal magnesium, where food alone may not be enough.

By Sandy Sanderson © 2025

REFERENCES:

(1)        Fujita, K.; Shindo, Y.; Katsuta, Y.; Goto, M.; Hotta, K.; Oka, K. Intracellular Mg2+ Protects Mitochondria from Oxidative Stress in Human Keratinocytes. Commun Biol 2023, 6 (1), 1–9. https://doi.org/10.1038/s42003-023-05247-6.

(2)        Toft, G.; Ravn, H. B.; Hjortdal, V. E. Intravenously and Topically Applied Magnesium in the Prevention of Arterial Thrombosis&#x2606; Thrombosis Research 2000, 99 (1), 61–69. https://doi.org/10.1016/S0049-3848(00)00215-2.

(3)        Ryazanova, L. V.; Rondon, L. J.; Zierler, S.; Hu, Z.; Galli, J.; Yamaguchi, T. P.; Mazur, A.; Fleig, A.; Ryazanov, A. G. TRPM7 Is Essential for Mg2+ Homeostasis in Mammals. Nat Commun 2010, 1 (1), 109. https://doi.org/10.1038/ncomms1108.

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Magnesium Deficiency in Dogs is the Number 1 Cause of Muscle Spasms
It is now well-known that dogs need all the essential vitamins and minerals that humans do. One of these key nutrients is magnesium because it’s needed for energy production at the cellular level. Magnesium deficiency in dogs can lead to a diverse set of symptoms. Every time your pet moves a muscle, experiences a heartbeat or has a thought, magnesium is needed to help them achieve this.
Fasting for Detox, Weight Loss and Energy
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Fasting for Detox, Weight Loss and Energy
Increasing your magnesium levels also supercharges the cleansing process. This is because magnesium supports detoxification by energising the detox enzymes such as glutathione and superoxide dismutase. These are powerful antioxidants, which neutralise free radicals and help to restore pH balance and energy production. This will give your metabolism a great boost - especially if you have been feeling sluggish and foggy, if the weight is piling on when it shouldn't be, or if you are battling with IBS and debilitating gut issues.
Pain Relief With the Most Important Mineral
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Pain Relief With the Most Important Mineral
Without the relaxation and antioxidant support of magnesium, the stress and tension increases acidity, weakens the immune system and microbiome balance, which promotes inflammation and headache.  These symptoms are common during influenza or coronavirus infections because they increase the stress and toxic load, thereby depleting more magnesium.
The Power of Magnesium in Water
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The Power of Magnesium in Water
When the body is dehydrated it can also cause oedema, a pooling of fluids around the ankles or puffiness around the eyes.   The reason for fluid retention is usually because the body cannot properly eliminate wastes when there is not enough free water flowing through the system. In order to protect the vital organs the body holds back and pools water in regions where the toxicity needs to be diluted most (eg. sites of inflammation or acidity). Waste products can also pool up and cause swelling in the lymph system - the body's protein waste disposal system. This is another case where toxic residues need to be diluted with more water.
Could Anxiety be Caused by a Toxic Gut Microbiome?
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Could Anxiety be Caused by a Toxic Gut Microbiome?
The microbial balance of our gut directly influences our Hypothalamic-Pituitary-Adrenal (HPA) axis, the production of hormones and neurotransmitters, and our immune system's regulation. Stress is very debilitating and causes depletion of magnesium because of excessive magnesium loss via the kidneys.  Magnesium deficiency causes energy depletion and acidosis, which triggers inflammatory states, resulting in moods swings, hormone imbalance, mental illnesses, fatigue, irritability, pain symptoms, and a weaker immune system. Magnesium deficiency also directly affects the beneficial bacteria, which thus leads to depressive-like behaviours.
The Most Important Mineral When You're Pregnant or Breastfeeding
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The Most Important Mineral When You're Pregnant or Breastfeeding
Magnesium is an essential mineral which performs some very important functions when you're pregnant. It’s used to maintain healthy blood sugar levels in the body (see study) and it helps build healthy teeth and bones by working in partnership with calcium. It also regulates cholesterol and irregular heartbeat.
Lose Weight and Improve Brain… by Sleeping
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Lose Weight and Improve Brain… by Sleeping
Magnesium deficiency or antagonism (blockage) can cause any one of these steps to malfunction, causing overdose of stress hormones and inability to relax enough to sleep deeply.
What is a Toxic Magnesium Dose?
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What is a Toxic Magnesium Dose?
It's almost impossible for you to get a toxic magnesium dose or overdose, unless magnesium is given at high dose intravenously, where there is no magnesium deficiency or the person has kidney problems and can’t excrete excess salts. 
What are the Dangers of Exercise Addiction?
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What are the Dangers of Exercise Addiction?
We can become addicted to more than just pharmaceutical drugs or alcohol.  Researchers are now noticing symptoms of addiction also to excessive exercise.  Does excessive exercise or over-training have negative side effects?  Could it harm health and cause premature ageing?  The research indicates yes, mainly because of increasing magnesium deficiency.
Is 'Overtraining Syndrome' Harming Your Health?
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Is 'Overtraining Syndrome' Harming Your Health?
Magnesium deficiency weakens performance, stamina and increases risk of injury When you push your muscles hard your brain is telling your body to ‘squeeze’ and act. Adrenalin and cortisol increase, and that helps push the calcium into the calcium channels of the muscle fibre cells, which makes them contract. Magnesium is temporarily pushed out of these channels during the contractions. When we relax, calcium comes out and magnesium moves back into the channels to relax the muscles again. 
Vitiligo and Hashimotos (Autoimmune) Hypothyroidism
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Vitiligo and Hashimotos (Autoimmune) Hypothyroidism
I was over 50 when menopause set in, accompanied by an autoimmune disorder called Hashimotos Hypothyroidism, severe heart arrhythmia, and the emerging white patches on my skin. This form of autoimmune hypothyroidism is thought to be prevalent in about 5% of the world’s population, however I believe the numbers are growing as people become more chemically sensitive to pollutants that stress the thyroid.
Immune System Defence with Vitamin C and Magnesium
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Immune System Defence with Vitamin C and Magnesium
The haemoglobin of red blood cells requires magnesium to help it take up oxygen from lungs and deliver that oxygen to tissue cells in other parts of the body. Researchers believe this is because, as part of the ATP energy currency, magnesium is vital to membrane integrity of red blood cells. The heme protein (containing iron) in these cells needs to ‘attract’ oxygen molecules from lung sacs as blood passes by. The oxygen molecules need to pass through the red blood cell (RBC) membrane – to get ‘onboard’ the train so to speak.
Drought, Dehydration and Stress
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Drought, Dehydration and Stress
Note that dehydrated states can cause feelings of anxiety where we just don’t know the reason for our fear or agitation, but the feeling persists.  Re-hydrating the body with ample water and magnesium can calm down these sensations because magnesium has a dampening effect on adrenaline and cortisol.  When the brain has ample water and magnesium we can think more clearly and make better decisions.  This is especially important during crises because our magnesium reserves can become dangerously low.
Protect Against Cardiovascular Disease With Magnesium
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Protect Against Cardiovascular Disease With Magnesium
Magnesium is so important to cardiovascular function, its scarcity being correlated with the development of cardiovascular disease, that it has become the focus of intense scientific study and review over recent years.  A meta-analysis review of epidemiological studies published in 2017 concluded that magnesium intake is associated with lower risk of major cardiovascular risk factors such as metabolic syndrome, diabetes and hypertension, as well as incidence of stroke and total cardiovascular disease.  Higher levels of circulating magnesium are also associated with lower risk of heart disease, mainly ischemic and coronary heart disease.
Calm Cramps and Restless Legs Fast!
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Calm Cramps and Restless Legs Fast!
You may not realise it, but cramps and restless legs are quite easy to fix and you can do it without drugs.  All you need is enough magnesium (and water) to get to where it is needed in the muscles for recovery and performance.
Can Magnesium Relieve Anxiety and Depression?
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Can Magnesium Relieve Anxiety and Depression?
As magnesium drops lower from excessive stress, there is less control over adrenaline and cortisol release, so that these catecholamines (stress hormones) escalate and chronically flood the system in a fight or flight (sympathetic) mode.  We can get stuck in that mode, unable to relax and move back to rest and recover grazing (parasympathetic) mode.  The stress hormones prompt glutamine to overstimulate neurons causing rapid and incessant calcium firing.  Without enough magnesium to control the calcium and switch off the catecholamine release, we can’t relax.
The Connection Between Magnesium and Ageing
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The Connection Between Magnesium and Ageing
It’s been coined the master mineral and deemed as critical as water. But how exactly does it correlate to the process of ageing? The ways are numerous, but we’ll highlight a few of our standouts. From menopause to migraines, bone health to beautiful skin, you’ll be eager to lather up in magnesium cream by the time you’ve finished reading this. And remember, even if you’ve had a blood test that did not show up a deficiency in magnesium, only a small portion of magnesium stores actually sit in the blood. There are other areas more likely to be depleted that won’t be detected so simply.
Magnesium Kids are Healthier
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Magnesium Kids are Healthier
Optimal nutrition for our children means they will have the best opportunity to realise their fullest genetic potential to be well balanced, healthy and happy into adulthood.  We all want our children to be ‘upgrades’ from ourselves. We want to pass on our seeds to future generations, but what about the quality of those seeds when magnesium is low? Can ‘magnesium kids’ offer a better hope for optimal health over a lifetime?
Collagen and Elastin Production for Skin, Muscle and Bone
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Collagen and Elastin Production for Skin, Muscle and Bone
Healthy cells need lipid protection, magnesium charge and ample hydration to support mitochondrial energy metabolism of Mg-ATP ‘batteries’.  This energy is then used to assemble amino acids into the various proteins we need to build collagen structures.  It is also used to manufacture hormones, enzymes, neurotransmitters and other chemical messengers.
Glyphosate: a Toxin Round Up That Steals Energy
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Glyphosate: a Toxin Round Up That Steals Energy
The review goes on to explain glyphosate’s mechanism of toxic action. Firstly, it is a strong chelating agent, creating complexes that immobilize the mineral micronutrients of the soil, such as magnesium, calcium, iron, manganese, nickel and zinc, making them unavailable to plants. This means that the food supply is robbed of vital mineral nutrients. We eat the food, it fills a void, but it doesn’t supply valuable nutrition. The end result is that we keep eating more and more empty carbs until obesity and other metabolic diseases such as hypertension, diabetes, senile dementia, inflammatory bowel disease, renal failure, thyroid or liver cancer develop.
Magnesium Soothes Pain and Inflammation
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Magnesium Soothes Pain and Inflammation
Inflammation and pain can be part of a healing crisis, but if your magnesium status is healthy you will heal and recover relatively quickly because the metabolism can perform the way it should. The lower the cellular magnesium levels get however, the slower it becomes to recover from the stresses and the more painful and amplified are the symptoms.
Menopause - No Big Deal Thanks to Magnesium
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Menopause - No Big Deal Thanks to Magnesium
Premature ageing is usually marked by excessive weight gain (especially adipose tissue around the middle), exaggerated dehydration, hypercalcemia, joint stiffening, acidosis and inflammation.  In other words, getting overweight, dry and stiff with creaky and brittle bones before our time. Skin can also get very dry and saggy looking. As we need magnesium to synthesise collagen proteins and elastin fibres, which are the structures that hold us together as skin, bone, ligaments, sinew, smooth muscle walls in arteries etc, low magnesium means those structures lose their integrity. [6]  Thus magnesium helps us to stay more hydrated, flexible and stretchy longer!
Magnesium and the Gut Microbiome
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Magnesium and the Gut Microbiome
Did you know that our gut microbiome needs a good supply of magnesium for energy to do all their jobs properly? Beneficial gut bacteria are extremely important to good health.  Did you know that we rely on our gut microbiome more than our own cells and enzymes for digestion of food and nutrient absorption?  If digestion is compromised we can be short-changed on magnesium uptake. Low magnesium can lead to feelings of depression, mood disorders, fatigue, restless and disturbed sleep, foggy brain, anxiety and much more.  See the STUDY: "Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour."